Acquire Blood Clot 10 times. grey, gray, deaths touch, death touch, Increases your chances to find an Angel Room instead of a Devil Room. The copy of you (enemy in the womb) will always shoot. Recharge time: Starts at 1 second, increasing by every time you use it. rocks, poop) in the room and deal 200 damage to all enemies in the current room, as well as every other room for the remainder of the floor, Also opens the boss rush door after Mom's Foot, blue womb door after Mom's Heart, secret rooms and super secret rooms, Like all single-use items, this item cannot be absorbed and used multiple times by the Void item, Entering a room with an angel statue will destroy it and automatically spawn one of the Angel mini bosses, REPENTANCE - This now blows up machines, beggars and fireplaces too, Upon use, this item will fart, pushing enemies away and causing a wave of rocks to spawn that spread outwards from Isaac in a circle, dealing 10 damage per hit to any enemies caught in it, Visually this item is very similar to Butter Bean, The rock waves can destroy destructible objects, e.g. Blood clots can form in veins anywhere in the body, including in the small veins under your skin or in the veins deep inside your body. Can be negated with Black Candle, Bad Gas - Isaac farts, poisoning enemies around him, Bombs are key - Switches number of bombs and keys, Explosive Diarrhea - Spawns five live troll bombs behind Isaac, one per second, Full Health - Restores all your empty red heart containers, Health Down - -1 HP. Isaac. Ram damage formula has changed to damage * 4 + 28 (previously dealt a static 40 damage). Unlocked from the 'Sin Collector' achievement (collect every Bestiary entry), Gulp! Using Sumptorium as her will then cause all Clots to be consumed and return your hearts back to you. 'One Makes you Larger' pills, Magic Mushroom etc, *, mtg, card, magic, gathering, green, brown, giant growth, Spawns 3 random cards on the floor when used, When used, this card will slow down enemies, Isaac's tears by -1 Shot Speed, but speed up Isaac's movement speed by +0.50 for the rest of the current room, UNLOCK: Unlock this item by getting both the Broken Watch and the Stop Watch in your collection, When used, removes the price tag from all items in the current shop or devil deal, making everything free, The effect of the Credit Card only lasts for the current room, UNLOCK: Unlock this card by beating Challenge #10 (Cursed!). * item room, treasure room, item room pool, money is power, dollar, red, grey, gray, Tears now have a random chance to freeze enemies in place, The chance to freeze enemies is affected by your luck stat, Chance to activate increases with luck, up to around 50% chance at +20 luck, UNLOCK: Unlock this item by collecting 3 'Mom' items in one playthrough, * item room, treasure room, item room pool, dungeon room, blood challenge room, arena pool, Every 40 seconds spent in the same room since last activating, when the timer displays 00, 20 or 40 seconds, a shield triggers, nullifying all types of damage for 10 seconds, As soon as Isaac has half a red heart or more, this item deactivates, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Lazarus, While firing tears this item gives you a chance to fire an eye across the screen with a very slow shot speed, which will fire tears of its own in the same direction as Isaac, The evil eye shots will be destroyed if they come into contact with enemies or obstacles, UNLOCK: Unlock this item by beating Greed Mode with Cain, Each time Isaac kills an enemy, you get a temporary +0.5 damage up which lasts for the current room, Each subsequent kill will stack further damage up to a maximum of +5 Damage Up after 10 kills, This item is the same principle as the Bloody Lust item from the original flash game, REPENTANCE - Added to the Devil Room pool, UNLOCK: Unlock this item by beating Greed Mode with Samson, Item Pool: Item Room, Devil Room, Greed Mode Item Room, After taking enough damage you will gain a permanent demon familiar, Possible familiars include: Dark Bum, Demon Baby, Leech, Lil' Brimstone, Succubus, Incubus, Lil Abaddon, Twisted Pair. Curses . ?, Satan and The Lamb as Tainted Lilith, All shops only sell familiars while holding this trinket, If you enter a shop while holding this trinket, the effect won't undo by dropping it until you move to a new floor, UNLOCK: Unlock this trinket by defeating Mother as Tainted Lilith, Every time an enemy dies you have a chance to gain a random Locust, Different color Locusts correspond to the horsemen. REPENTANCE - White Pony's charge time has been reduced to 2 (from 6). ?, Satan and The Lamb as Tainted Jacob, Gives you a familiar that follows Isaac's exact movements (similar to how Jacob & Esau work) and shoots spectral tears, Similar to Jacob and Esau, positions can be altered by running it into objects, or holding the drop button (Ctrl on Steam version), When you place a bomb, the Found Soul will drop one too, If it takes any damage, it will die and not respawn until the next floor, UNLOCK: Unlock this trinket by defeating Mother as Tainted Jacob, Everytime you use your active item, you have a chance to activate another random active item, Glowing Hourglass effect is blocked from this item, UNLOCK: Unlock this trinket by defeating Isaac, ?? The barrage of knives goes all the way across the screen and does not return. It's a 20% chance on first miss, 33% for a second miss and 50% for anything beyond that, Piercing shots work with this item and multiple hits with a single tear will each give a damage bonus, *, bullseye, target, grey, gray, black, red, circle, Isaac has a random chance to fire a Holy tear, which when it hits an enemy, will spawn a light beam on the same enemy, dealing damage, The beams from this item deal damage equal to 400% of your tear damage (4x damage multiplier for the beams only), The chance to fire a Holy tear is affected by your luck stat, maxing out at a 50% chance, Item Pool: Item Room, Greed Mode Item Room, Angel Room, A familiar host that sits on Isaac's head and has a 20% chance to block enemy shots, When a shot is blocked, Host Hat will fire 3 bullets back at the enemy, Causes you to become immune to explosions, but doesn't protect against stomps or shockwaves, Causes your shops to instantly restock their items when you buy them, New items generated by Restock are from the shop item pool, The cost increases exponentially every time you purchase an item. REPENTANCE - Kidney Bean now has a bigger effect radius, no longer deals damage to the enemies it's charming, and charge time has been reduced to 1 (from 2). Based on the Steam Workshop mod created by Maddogs, UNLOCK: Unlock this item by picking up Rubber Cement 5 times, Spawns 3 red hearts on the ground when picked up, Added as part of the Afterbirth+ Booster Pack #5, UNLOCK: Unlock this item by defeating Mom's Heart on hard mode as The Forgotten, This item gives you an orbital, which will reflect projectiles back at enemies, Unlike some other orbitals, Slipped Rib doesn't deal contact damage to enemies, UNLOCK: Unlock this item by defeating the Isaac boss as The Forgotten, A familiar which follows Isaac and spawns a white poop when you take damage, The white poop gives an aura that cuts your tear delay in half (Tears up) and has a chance to block damage, The aura disappears if the poop is destroyed. Also works for opening Spiked Chests and Mimic Chests without taking damage, When used, this item restarts the game and places you back on the first floor with all your currently collected items, similar to doing a Victory Lap, Allows angel rooms to be found in the new run if a devil deal was taken in the first run, In Greed Mode and while playing as Tainted Keeper, this item costs 99 coins instead of 15. The term "brimstone" (burn stone) comes from the King James Bible's mention of burning sulfur. After killing a 25 more enemies, it transforms again dealing 15 damage and destroying obstacles it charges into. Blood Clot / Chemical Peel / The Peeper: 50% chance to apply the flat damage up/damage increase with each shot. UNLOCK: Unlock this item by defeating Mother in the Corpse II as ??? White poop Dips have a small Hallowed Ground aura effect, increasing your damage and fire rate while standing in it. shop item pool, x, paper, Makes all of Isaac's familiars stronger and bigger, Causes most familiars to deal double damage, Has no effect on most familiars that scale with Isaac's tear damage, * key master pool, key beggar pool, key judgement pool, shop room pool, shop item pool, red, heart, ?, Satan and The Lamb as Tainted Forgotten, Gives you +1 Bone Heart every time you enter a new floor, UNLOCK: Unlock this trinket by defeating Mother as Tainted Forgotten, Dropping this trinket again removes the transformation if you dont have 3 other Guppy items, UNLOCK: Unlock this trinket by defeating Isaac, ?? * secret room pool, item room, treasure room, item room pool, 25, grey, gray, silver, devil pool, devil room pool, devil deal, Converts most negative pills into their positive counterparts, e.g. If you have PhD it will only increase one stat, Can be used multiple times, but every time you use it, it has a chance to disappear, The Gold Pill can spawn as a Horse Pill, which then causes it to give random Horse pill effects, UNLOCK: Unlock this by defeating Mega Satan as Tainted Cain, Horse Pills rarely spawn as larger versions of normal pills with more powerful effects, Items that synergize with pills also have the same effect with Horse pills, In general, the effect of a Horse Pill is double the effect of a normal pill i.e. Items Challenges Rarer clots have unique effects on tearsBone Clot tears have Compound Fracture, Gold Clots have Midas Touch, Eternal Hearts have Sacred Heart, and Black Hearts have Dark Matter. on enemy death, on room clear, on damage taken etc. The beam is piercing and spectral, dealing damage to all enemies and ignoring all obstacles in its path. Kicking a frozen enemy will push it into the wall, where it shatters and fires ice shards everywhere (these can then freeze other enemies), Isaac will now automatically charge up tears, allowing you to store them up and fire them rapidly for a short time, Any time you aren't firing tears, the charge bar will start filling up, for up to 3 seconds. Objects When used, it retrieves the Forgotten skull, causing it to shoot back into your arms, Tainted Bethany - Spawns four random item wisps of high quality with significantly higher HP than normal, Tainted Jacob - Dark Esau splits into 2. This deals 1 damage per tick, High tear damage will cause this item to become very powerful for rooms with a lot of enemies, since they can die instantly and render the room harmless, Enemies which spawn after the first few seconds of each room are not affected by this item, e.g. Gives a small chance when entering a room for enemies to be petrified for 4 seconds. REPENTANCE - Bombs no longer knock each other around when the player has Fast Bombs, allowing for a more controlled line of explosions. Stat Up becomes Stat Down), Any 'Stat down' pills you take give you a permanent +0.6 Damage Up (Horse pills +1.2), Most other pills spawn a black heart when used, including R U A Wizard?, Amnesia, Bad Trip, ?? A clot blocking blood flow to the brain can lead to a stroke. Deals significant contact damage to enemies while active (1600 dps). ?, Paralysis, Retro Vision, I'm Excited, While held, gives you an orbital that blocks enemy shots and deals contact damage equal to 3.5 per tick, While the active key is held down, Isaac gains +0.5 Speed and all of your orbitals spin faster and deal more damage, Orbital damage is equal to 1.5 x OrbitalDamage + 6 while this effect is active, On death enemies now fire tears in random directions, which can damage other enemies, The amount of tears created by this effect depends on the total health of the enemy killed. (D20 effect), 3 Dot - Rerolls all pickups on the entire floor, 4 Dot - Rerolls all pedestal items on the floor. Seeds Ultra Secret RoomTreasure RoomTreasure Room or Satan), The Wafer becomes most effective in the Womb and beyond where enemies all deal a whole heart of damage, The Wafer causes the Sharp Plug item to only cost 1/2 a heart per use, Has no effect with the Keeper - there's no such thing as half a coin health point, * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, Bosses Manage all your favorite fandoms in one place! . Cain no puede disparar lgrimas . The most common signs are crushing chest pain and difficulty breathing. Multi-shot effects add 1 bomb to the barrage, up to 21 bombs. The signals tell your spleen to release . pill if no other pills were used yet. The more items in a pool, the more likely that pool will be picked, A familiar grey spider that wanders around and allows you to see your tear damage and the health bars of all enemies, The spider will inflict a random status effect on any enemies it comes into contact with (e.g. red, bolt, cupid arrow, cupids arrow, When used, fires a high damage laser in a straight line across the room in a similar way to Brimstone, The laser deals damage equal to double your tear damage. Does not apply Monstro's Lung's tears down. Cube of Meat after defeating a Horseman, REPENTANCE - It is now possible to see items again that have been rerolled away, preventing emptying the item pool and 'Breakfasting', REPENTANCE - Chaos now assigns a "weight" to item pools based on how many items are in the pool. paper, roll, white, All of Isaac's bombs now having a homing effect when placed on the floor, * boss rush pool, boss rush room, item room, treasure room, item room pool, bomb beggar, dead, UNLOCK: Unlock this item by defeating Mother in the Corpse II as Eve, When used, this item does a shout-type attack, with its effect increasing in damage and size the more charges you have, Larynx can be used with any number of charges. It returns after a room has been cleared, UNLOCK: Unlock this item by beating Greed Mode with Eden, Item Pool: Item Room, Secret Room, Greed Mode Shop, *, red, yellow, green, white, square, rectangle, When used, the D8 rerolls all of your stats, Will only effect your damage, tears, range and speed stats, Each stat is given a multiplier that applies after all other adjustments, UNLOCK: Unlock this item by beating Challenge #28 (Pride Day), * dice, pip, die, black, grey, gray, pyramid, triangle, Purity will boost one of Isaac's stats depending on the colour of the aura around him, When you take damage, the aura will be removed and replaced with another random one when you enter the next room, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Maggy, Item Pool: Item Room, Angel Room, Greed Mode Item Room, Greed Mode Angel Room, Adds a chance for a black ring to spawn around killed enemies, dealing damage to others that touch it, The ring damage scales with your tear damage, The change for a ring to spawn scales with your lucky stat, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Eve, Item Pool: Devil Room, Curse Room, Greed Mode Devil Room, *, grey, gray, silver, metal grabber, hand, robot, When Isaac has no red hearts, this item gives Isaac the ability to fly. 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